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Use Caution/Monitor. If used, choose an agent with a shorter half-life. lorazepam and motherwort both increase sedation. Monitor Closely (1)diazepam and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serious - Use Alternative (1)hydrocodone, lorazepam. lorazepam decreases effects of atracurium by pharmacodynamic antagonism. lorazepam and pholcodine both increase sedation. If necessary, adjust dose of alprazolam as needed, Monitor levels of digoxin, and reduce dose as needed, Adjust dose of diazepam as needed, or change to a benzodiazepine eliminated by glucuronidation, Reduce starting dose of alprazolam by 50%; adjust dose further as needed, Alprazolam, diazepam Fosamprenavir (Lexiva), Chlordiazepoxide, clonazepam ketoconazole, Diazepam, lorazepam olanzapine (Zyprexa), Increased risk of cardiorespiratory depression, Avoid use of parenteral benzodiazepines and IM olanzapine, Diazepam phenyton (Dilantin), fosphenytoin (Cerebyx), Monitor phenytoin levels, and adjust dose as needed, Reduce lorazepam starting dose by 50%; adjust dose further as needed, Alprazolam, clonazepam, diazepam ritonavir (Norvir), Alprazolam, diazepam saquinavir (Invirase), Increased sedative/CNS depressant effects, Monitor for sedative effects, and adjust dose of one or both as needed, Monitor for increased sedative/CNS depressant effects, Start tapentadol at 1/3 to 1/2 the usual starting dose. Step 1- Starting dose of lorazepam PO q6h x8 doses (see above calculation) 2. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and isoproterenol decreases sedation. For more information, please refer to our Privacy Policy. Use Caution/Monitor. brimonidine increases effects of lorazepam by pharmacodynamic synergism. Monitor Closely (1)lorazepam and moxonidine both increase sedation. Monitor Closely (1)lorazepam and diamorphine both increase sedation. cont. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. lorazepam and quazepam both increase sedation. Former Nurse Charged With Murder in Death of 97-Year-Old War Veteran. WebLorazepam (PO/IV): 0.025 - 0.1 mg/kg/dose (Max: 2 mg) Q4-6 Midazolam (PO) 0.25 - 0.5 mg/kg/dose (Max: 20 mg) PRN Voriconazole (IV/PO) 2 - 12 yo: 9 mg/kg/dose x 2 doses then 8 -9 mg/kg/dose Q12 12 yo: 6 mg/kg/dose x 2 doses then 3 - Effect of interaction is not clear, use caution. pentobarbital and lorazepam both increase sedation. lorazepam increases and methamphetamine decreases sedation. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown. Dose Equivalent to 10 mg Diazepam Available Tablet Strengths Duration of Action* Half-Life** (hours) Alprazolam (Xanax) 0.5-1 mg 0.25 mg, benzhydrocodone/acetaminophen, lorazepam. Monitor Closely (1)lorazepam and ziprasidone both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Minor (1)zolpidem, lorazepam. Use Caution/Monitor. Monitor Closely (1)lorazepam and droperidol both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. lorazepam and oxycodone both increase sedation. Minor/Significance Unknown. 3 0 obj
Use Caution/Monitor. Use Caution/Monitor. lorazepam and trazodone both increase sedation. Check out 22 similar dosage calculators , Benzodiazepine half-life & benzodiazepine classification, Benzodiazepine equivalency table benzo conversion chart. Effect of interaction is not clear, use caution. Use Caution/Monitor. Modify Therapy/Monitor Closely. WebAntipsychotics for initial management of the acutely agitated adult patient with psychosis. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor Closely (1)lorazepam and tapentadol both increase sedation. Compare it to your result computed with our benzodiazepine conversion calculator. Patient demographics, We're going to present a definitive benzo conversion chart, benzodiazepines classification, and the details of every drug's mode of action. Limit dosages and durations to the minimum required. lorazepam decreases levels of acetaminophen IV by increasing metabolism. Monitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. Use Caution/Monitor. lorazepam and apomorphine both increase sedation. Effect of interaction is not clear, use caution. 81 0 obj <>
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Use Caution/Monitor. diphenhydramine and lorazepam both increase sedation. Greenblatt DJ, Shader RI, MacLeod SM, et al. Monitor Closely (1)dimenhydrinate and lorazepam both increase sedation. Monitor Closely (1)lurasidone, lorazepam. rifabutin decreases levels of lorazepam by increasing metabolism. Either increases effects of the other by sedation. Either increases toxicity of the other by pharmacodynamic synergism. lorazepam and temazepam both increase sedation. Use Caution/Monitor. For information regarding this article, E-mail: [emailprotected]. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. %PDF-1.6
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prescription products. Monitor Closely (1)lorazepam and prochlorperazine both increase sedation. Monitor Closely (1)lorazepam and buprenorphine both increase sedation. Serious - Use Alternative (1)lorazepam, metoclopramide intranasal. cinnarizine and lorazepam both increase sedation. lorazepam, pyrimethamine. Use Caution/Monitor. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. Monitor Closely (1)lorazepam increases and salmeterol decreases sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and topiramate both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and nabilone both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)lorazepam and mirtazapine both increase sedation. Minor/Significance Unknown. sage decreases effects of lorazepam by pharmacodynamic antagonism. For children older than 6 years of age, use 5 mg two to four times a day. Monitor Closely (1)lorazepam and temazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Use Caution/Monitor. Use Caution/Monitor. endobj
lorazepam and aripiprazole both increase sedation. Monitor Closely (1)lorazepam increases and caffeine decreases sedation. Otherwise, call a poison control center right away. 0000003285 00000 n
esketamine intranasal, lorazepam. Patient demographics, benzodiazepine dose escalations, as needed benzodiazepine requirements, and severe adverse events within 48 hours of conversion were assessed. Increased CNS depression. Use Caution/Monitor. Use Caution/Monitor. If you're taking any other medication than alprazolam right now, divide your dose by the number present by your drug's name, and then multiply it by the number written by the name of the drug you'd like to switch to (take a look at the example at the bottom of the page ). Modify Therapy/Monitor Closely. DB - Johns Hopkins Guides Effect of interaction is not clear, use caution. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. This work was performed at the Childrens Hospital of Philadelphia. lorazepam and loxapine both increase sedation. lorazepam decreases levels of levocarnitine by unspecified interaction mechanism. Monitor Closely (1)lorazepam and imipramine both increase sedation. Initial dose should not exceed 2 mg in Use Caution/Monitor. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. Most Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. 0000010283 00000 n
Use Caution/Monitor. Monitor Closely (1)lorazepam increases and phendimetrazine decreases sedation. remimazolam, lorazepam. Monitor Closely (1)lorazepam and quetiapine both increase sedation. butalbital and lorazepam both increase sedation. lorazepam and ramelteon both increase sedation. lorazepam and deutetrabenazine both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Effect of interaction is not clear, use caution. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. 0000004769 00000 n
alprazolam and lorazepam both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. lorazepam and eucalyptus both increase sedation. Use Caution/Monitor. 0
Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. primidone and lorazepam both increase sedation. Use Caution/Monitor. H\TKoAqs;O Use Caution/Monitor. Read more about Benadryl by visiting the benadryl calculator. je 8&K`Y/ o *C'lvpeKBg6CK pIE-azD-`[\s2q&o|in(J|6iT1t>aRkDXs(z%7;PS d\c1"4S#8jk*TR78IgnR(kv Monitor Closely (1)lorazepam increases and ephedrine decreases sedation. lorazepam increases and norepinephrine decreases sedation. Avoid or Use Alternate Drug. Want to screen for generalized anxiety disorder (GAD) and its severity? Use Caution/Monitor.Minor (1)dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor (1)fleroxacin increases levels of lorazepam by decreasing metabolism. This conversion from intravenous (IV) to oral (PO) thera-py has been practiced in an uncon-trolled fashion since the earliest years of the anti-infective era. Use Caution/Monitor. lorazepam and papaveretum both increase sedation. .2/ZfG[:{oH}ZJUmniOF F.\6K"abU:hiVyz6gAKt_|pgrqx9MUWz,_LgMvU ?>MJx
'A7 gk\nd^=zff3plgZn7GL:nnL0R2 \mSKu-08W}yx8m}R,Q3}Mm