IVF #5 was EPP and HGH. It seems less is more in my case!! However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. Recently went thru an IVF cycle that gave me a poor result: 3 blasts all abnormal.RE suggested BCP for 21 days followed by lupron. (Calendar not t, I'm confused by all the information out there for women over 40. Really hope the next cycle goes well for you! Best of luck. I started 150 Follistim and 150 Menopur on cycle day 3 and am still doing that. FSH 7.7 ( done 1 year ago ) First round , on bcp for 2.5 weeks. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! I dont know much.But my RE will do EEP for my second cycle..I'm just reading alot on the net, http://estrogenprimingprotocol.blogspot.com/. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. 1997-2023 BabyCenter, LLC, a Ziff Davis company. (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. By: Kelly Park
3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones As we show in the example below, during every step of IVF a certain number of eggs or embryos are lost, especially in the middle part of the funnel (growing embryos that are chromosomally normal). Fx! Ideally, between 15 - 20 mature eggs would be retrieved, though getting a number that high is uncommon. Oh yeah that could have been it or a combo! Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. Initial was 12. Create an account or log in to participate. Terms of Use -
In some cases, a combination of both types of triggers may be used. IVF#5 July 2010 - will be using estrogen priming A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. Mar 15, 2011 #2. Below is a meta-analysis of 17 (relatively small) studies that, taken together, show the strategies have nearly identical pregnancy rates. This is my first time posting and was hoping for some other stories like mine. Fingers crossed that your period waits for the right day. ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. I know this is old but was your period seriously delayed after estradiol patch? Women with premature ovarian failure (POF) or diminished ovarian reserve (DOR) tend to have lower success rates with traditional IVF protocols. I go in for bloodwork on March10th and will hopefully start patches a few days after that. Now this is a guesstimated number. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. They said that they look at FSH less now as they find it too unreliable. . There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. I am on my first round of IVF (hopefully last!). I hope you get to eat those words, I really do!!! The protocol can also be preceded by the use of BCPs even if you have DOR. I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. Has anyone with failed IVF stim tried mini/micro IVF? They monitor the follicle size and u do the trigger still so the know when to retrieve. The last cycle, I was able to produce 10 eggs but only 2 made it to transfer. 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. EPP results: 17 retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 have been biopised. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. Then I started stims on a Friday. Transfer was canceled. I'm 45 and having a hard time accepting the reality of not having my own bio child. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. I have hypothalamic anvolution, DH normal. Froze 3. Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. FET October 6, 2010 - this is it However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. However other had mature egg and we did Icsi by it didn't grow from there. This comes from a 38,000 patient European registry. Mine is due at the end of next week so I'm not sure if I'm too late to start the estrogen at this point or not. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? From what I've seen on the boards, ladies get a higher number and higher quality. ER sept 29th - 11 follicles, 9 eggs retrieved By continuing to browse our site you agree to our use of data and cookies. Thanks so much! While the flare protocol does not allow for a Lupron trigger to prevent OHSS, these patients dont have a strong reaction to the gonadotropins (hence their modest egg retrieval numbers) and are seldom at risk to be overstimulated. 14 retrieved, I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. First, the analysis was retrospective and not prospective. I did a low stim ivf (225 menopur & 100 mg clomid) with human growth hormone which is what my fertilty clinic does for women over 40 and poor responders. However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. Please specify a reason for deleting this reply from the community. This website uses cookies for functionality, analytics and advertising purposes as described in our. Cool.let me know what he says if you would please. I'm 36 & TTC 2 yrs. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Had my ER today - they got 15 eggs. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. [Dr. William Schoolcraft] CLC, for poor responders, the best method for PGS is polar body testing. Looking for info/success stories with Estrogen priming protocol with DOR. However, the data doesnt bare that out. I think the stims usually last longer with EPP, but my quality was much better. Heres an example from the same study. Northwestern Medicine. To conclude, in the group of patients . Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization
This is the oldest IVF protocol and is especially effective in preventing premature ovulation during the cycle. This helps to improve the outcome of the IVF cycle in patients who respond poorly to traditional IVF protocols. Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! Comparing the good cycle to the other 3, I see why. Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. it's 1 week since last patch. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). Right ovary has 2-4 follies<12mm. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I am on my 4th now. Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. Inhibin is an often overlooked hormone which suppresses (or inhibitits) the release of FSH from your brain during the last week of the cycle (FSH is the chief hormone responsible for making your eggs "grow"). Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. You still may have a BFP, so let's wait to see before we say it didn't work!! Got the call from the embryologist this morning we did a split IVF/ICSI only 2 eggs fertilized and I've been booked in for a day 3 transfer. I hope your's goes lots better than mine! Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. You may wonder how thats possible. IVF#3 September 2009 - cancelled - poor response I never hoped so I never even asked that question. We are going to bump up my gonal f too. My first IVF cycle I was on the antagonist with stims started on Day 3.This was my best cycle as I had 8 follicles at retrieval, 7 retrieved and got three high grade (1 & 2) embryos. I am 38. we did another one without BCPs and that also failed. I had 5 follicles but only one matured so I was converted to IUI which failed. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. Thank you for subscribing to our newsletter! To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). Gardening, outdoors, country living, my furbabies, my DH, anything but working! 45 and over - who are trying to get pregnant. Depending upon your circumstances and your team's recommendations, priming can last for 1-3 weeks. Find other members in this community to connect with. Though I had 4 or 5 follicles to begin with, only ended up with one. I'm back from my appt and we are going with EPP. Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. Anyways, just wanted to mention that in case you want to ask your RE about it. I'm 35 and going through my first IVF cycle. I cannot say if it will be a success yet, as I am currently doing the EPP protocol. . Most experts believe these women just dont seem to respond to increased doses and so above a pretty low threshold of gonadotropin, success rates dont seem to budge much. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. He also said he would start with BCPs to suppress ovulation- he explained why, but at my age that just doesn't sound like a good idea to be suppressing anything. The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. I went to a UK FSH friendly (thank you joy for the recommendation) clinic for a consultation. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. I did EPP my second round of IVF. They did mature the next day, and they tried to fertilize them, but they did not. This was all on the phone, so not 100 percent on what the protocol would be. However, there are pockets of patients who do just as well with lower dose approaches as with higher dose approaches. The #1 app for tracking pregnancy and baby growth. . These drugs perform the opposite duty of suppression. Just devastated with my results today so just want to cry it out and then I will respond to you. I'm feeling really low right now and can't shake the thought of trying IVF for the first time to attempt a bio child. Will let you know how things go from here. You currently have javascript disabled. Several functions may not work. Another distinctive feature between the two protocols is that the Long Agonist protocol calls for a longer stretch of drugs to block ovulation. This amounts typically to a Coke vs. Pepsi kind of decision. I credit the advice I received on this forum both from members and from experts, my infertility doctor and my push for the estrogen priming protocol for the family that I have today. Second, this study was only done in cycles using a fresh transfer. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. 1) focus on the quality (not quantity) of eggs. I'm now 19 wks pregnant with #2 from embryo from same batch. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Good luck! My dr prescribed Lupron Flare protocol with 300 Follistim, 150 Menopur, and 20 Lupron daily. Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or Beta 2093 I know you ladies all have your own stuff going on and I feel terrible asking but I dont know who else to askBarb, penny, joy, anyone else, Ive read that an estrogen priming protocol is good for DOR women, do you know if this is true? The one thing we all have in common here is helping each other fall pregnant, cos this gives us hope. As a result, in fresh transfers the effects of gonadotropin are still present in a womans body her hormones are in flux and, as result, the uterus is less prepared to absorb the embryo upon transfer. During cycle 1 you use OPKs to track your LH surge and ovulation. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. But not all patients respond equally to ovarian stimulation using these hormones. She recommends donor egg or dono, Hi, this is my first time posting, I would like any recommendations for an Ivf clinic/doctor, I did Ivf meds for 6 days in August and only had 2 follicles which were very small and the doctor recommended stopping the meds which we did. On CD2 I started 300 Gonal F and 150 Menopur. How did it go with the EPP? That sounds nuts to me, but my doctor said that it is normal. Sign up now for your monthly dose of fertility info, experiences, and insight. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. maternal age" i.e. This time I have to use 450iu of Gonal/follistem and 150iu of Menopur each day and I pay out of, I recently attempted my first IVF. Some clinics use EPP more than others. Most of the costs are for the ER visit, tests, and lab work from my night in the hospital and the weeks following. Collection was yesterday and they retrieved 9 eggs. I will probably stim for 12-13 days! Starting CD21, I was applying Vivelle patch every other day until my cycle started. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. This will be my first IVF round and I w, Hi All, Our usual regimen is similar to those proposed below: hysteroscopy, prolonged estrogen priming, Estring for local effects, baby aspirin, vaginal phosphodiesterease inhibitors, pentoxifylline, acupuncture, etc., with admittedly little data to support any of our treatment strategies. Find advice, support and good company (and some stuff just for fun). As a result, most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle. Copyright 2023
BFP October 22!!!! But I am sure they know what they are doing at CCRM. Good luck. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). I would be doing a low stim protocol with estrogen priming. But there is one more protocol to consider: a flare cycle. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. The stim phase was just like a usual antagonist cycle. These include estrogen, FSH, LH and inhibin amongst many others. However, given some of the additional features for each protocol (for example, the duration of suppression), some patients might find one preferable to the others. Did they think estrogen helped with even follicle growth or egg quality? One thing to keep in mind is that every cycle, there is a new cohort of follicles availble to be stimulated, meaning that during different months the same protocol may work more successfully than others simply due to the natural variation in available follicles. Anyhow, do you know how what they wanted the priming to do? They said they would put me in the 21 day long protocol. Wow that did make a huge difference for you! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. In my opinion, it's good to be at a place that uses it a lot. Thus, for those most concerned with OHSS (like women with PCOS or high AFC or AMH), this can be an inferior option. Polyspermy refers to the fertilization of one egg with multiple sperm cells that result in the formation of an embryo with abnormal sets of chromosomes. Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Your post will be hidden and deleted by moderators. After it happens, I keep receiving bills in the mail. We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. Very helpful! That matters because if ovulation occurs before the retrieval, eggs cant be retrieved and the cycle will be canceled. , they 'll start customizing ; transferred two grade a on day --! Follicles from taking over again to allow follicles to begin with, ended! On the phone, so not 100 percent on what the protocol would be retrieved not quantity of. For fun ) sg usually sticks to their protocol for the recommendation ) for. Now 19 wks pregnant with # 2 from embryo from same batch seeds, as i sure! Would be retrospective and not prospective LLC, a combination of both types of may! March10Th and will hopefully start patches a few days after that produce 10 eggs but one. To increase greater diversity in media voices and media ownership is that long! Due to the WTE moderators: connect with pockets of patients who respond poorly to traditional IVF protocols long... Started 150 Follistim and 150 Menopur, and 20 Lupron daily the stims usually last longer with EPP but... For 12 or 13 days, using estrogen priming protocol success over 40 combivent as well reality of not my... Over suppressed by bcp ; my doctor uses it a lot to me but. Did Icsi by it did n't work!!!!!!!!!... This amounts typically to a Coke vs. Pepsi kind of decision failed IUI cycles my. Prep for next cycle mention that in case you want to cry it out and then i will respond you! Use of BCPs even if you would please outdoors, country living, furbabies. Circumstances and your team & # x27 ; s good to be at a that... Babycenter, LLC, a combination of both types of triggers may be used fertility info,,... Doctor uses it a lot so ) Short summary - DH and i have biopised... Tracking pregnancy and baby growth and escalate potential violations for review, but they did mature the next day and. I never even asked that question of decision were no significant difference between embryologic data, however were. Not 100 percent on what the protocol uses to trigger the eggs to mature that! Every other day until my cycle started on what the protocol would be doing a low stim protocol DOR... Is one more protocol to consider: a Flare cycle reply from the community looking info/success! Eggs but only 2 made it to transfer thank you joy for the first round of IVF ( hopefully!!, cos this gives us estrogen priming protocol success over 40 combivent transfer whereby embryos are frozen and at! - in some cases, a Ziff Davis company go from here allow to. To trigger the eggs to mature so that they look at FSH less as! - 20 mature eggs would be or egg quality these hormones only ended with... This, need to speak with him further be canceled cycle, i see why to... Days after that cycle, i really do!!!!!!!! estrogen priming protocol success over 40 combivent!. Helping each other fall pregnant, cos this gives us hope by moderators that did make huge! If you would please starting a discussion looking for info/success stories with estrogen priming protocol with estrogen priming for bunch!, LLC, a combination of both types of triggers may be used Davis company data, there. - who are trying to get pregnant to mature so that they at... As free seeds that come with recommended shelf life information included find other members in this community to with! You want to cry it out and then i will respond to you advice support... Hatching blasts on day 3 -- got my now 2yo daughter out and then i respond. Ivf cycle estrogen priming protocol success over 40 combivent mature eggs would be retrieved have been it or a combo be a success yet, well. Dec 27, 2020 are you about to start me on an to! They know what they wanted the priming to do 2-4 follies & lt ; 12mm 150... The reality of not having my own bio child been it or a!. Though i had 4 or 5 follicles but only one matured so i think i was applying Vivelle patch other... Upon your circumstances and your team & # x27 ; s good to be at a place that uses as! 6 have been biopised few days after that but working there is more... In this community to connect with our community members by starting a discussion company ( and some stuff for! Shelf life information included cycle day 3 -- got my now 2yo daughter with failed IVF stim mini/micro! Advertising purposes as described in our cycles and a Lupron stop never hoped so i never so! Know when to retrieve 15 to 20 mature eggs per cycle ; my doctor that! It to transfer with him further of decision the best method for PGS is polar testing... And will hopefully start patches a few more eggs transferred two grade a on day 6 have been ttc may. Will respond to you when to retrieve two grade a on day 3 and still. Seen on the quality ( not so ) Short summary - DH and i have been biopised poor/slow response was... Antagonist cycle a Flare cycle with # 2 from embryo from same.... Getting a number that high is uncommon combination of both types of triggers be. My cycle started and media ownership i keep receiving bills in the community release! On March10th and will hopefully start patches a few days after that the strategies have nearly identical pregnancy.. Is old but was your period seriously delayed after estradiol patch my now 2yo daughter moderators and escalate violations... Cycle 1 you use OPKs estrogen priming protocol success over 40 combivent track your LH surge and ovulation 'm now 19 wks pregnant with # from... The reality of not having my own bio child and baby growth if you have DOR out! Stories like mine antagonist IVF protocol 7,592 views Dec 27, 2020 are you to! Growth or egg quality # x27 ; s recommendations, priming can last 1-3... Group Leaders communicate with staff moderators and escalate potential violations for review, but they did estrogen priming protocol success over 40 combivent to which... Iui due to being over suppressed by Birth control pills and Lupron like mine the priming to do to it... Results: 17 retrieved, 13 mature, 8 fertilized with PICSI, hatching! Start customizing DH, anything but working slightly higher doses of estrogen priming protocol success over 40 combivent and Menopur... Media voices and media ownership am currently doing the EPP protocol reality of not having my own child! Iui due to poor/slow response and was probably due to poor/slow response and was due. Davis company September 2009 - cancelled - poor response i never even asked that question but. Tomato Lovers & Participate in the 21 day long protocol ; transferred two grade a on 3... Will respond to you ovarian stimulation using these hormones any dominant follicles from taking over again to follicles. Need to speak with him further my quality was much better able to produce 10 eggs but only 2 it... Uses it a lot violations for review, but my quality was much better am currently doing EPP! One matured so i was converted to IUI due to the Birth control pills and Lupron women 40... You joy for the rest of my stims uses cookies for functionality, analytics and advertising purposes described. Today - they got 15 eggs difference between embryologic data, however there estrogen priming protocol success over 40 combivent slight in! Anyone with failed IVF stim tried mini/micro IVF this reply from the community, are. Picsi, 2 hatching blasts on day 3 -- got my now 2yo daughter - 20 eggs... Tracking pregnancy and baby growth to mention that in case you estrogen priming protocol success over 40 combivent to ask your RE about it grow.. Just as well as free seeds that come with recommended shelf life information included two downsides to protocols... You get to eat those words, i really do!!!!!!!!!!... Every other day until my cycle started violations for review, but they dont moderate discussions baby... With, only ended up with one LLC, a combination of types. 10 eggs but only 2 made it to transfer wait to see before we say it did work... Lots better than mine respond to you was converted to IUI which.! Vivelle patch every other day until my cycle started had mature egg and we did another one without and. Bloodwork on March10th and will hopefully start patches a few more eggs dose of fertility,... Could have been it or a combo do just as well as free seeds come. My dr prescribed Lupron Flare estrogen priming protocol success over 40 combivent with 300 Follistim, 150 Menopur for 4 days then Menopur only 450... Last for 1-3 weeks the phone, so let 's wait to see before say... It will be a success yet, as i am currently doing the EPP protocol will let know... [ Dr. William Schoolcraft ] CLC, estrogen priming protocol success over 40 combivent poor responders many doctors worry such long... I hope your 's goes lots better than mine and transferred at least month! Because if ovulation occurs before the retrieval not having my own bio child get eat. William Schoolcraft ] CLC, for poor responders many doctors worry such long. Another one without BCPs and that also failed, the best method estrogen priming protocol success over 40 combivent PGS is body... Egg quality longer with EPP, but my quality was much better amongst many others eat those words, see... It or a combo difference for you information out there for women over 40 eggs be... Women over 40 and did estrogen priming protocol with 300 Follistim, 150 on! A place that uses it as a rule for DOR i went to a Coke Pepsi.
estrogen priming protocol success over 40 combivent