Amazon.com: Melanin Research Foundation: Books 1 result RESULTS Melanin: Energy from Light and the Soul's Ascent by Melanin Research Foundation | May 3, 2015 20 Kindle $399$6.12 Available instantly Paperback $612 FREE delivery Sat, Dec 10 on $25 of items shipped by Amazon Need help? 18. Adapted from Ref. 2 (April 1961): 440-41,https://doi.org/10.2307/1932103. 6 (December 2008): 525-31,https://doi.org/10.1016/j.mib.2008.09.013. The first known organic semiconductor,15it is a black substance prominent in eyes, skin, hair, scales, and feathers, and it can also be found in the mammalian central nervous system. The Pineal gland is the first gland developed in your body, and appears in homo-sapiens a mere 3 weeks after conception. Given its function as an evolutionarily encoded heuristic that has allowed the human brain to rapidly identify in-group versus out-group dynamics, it has played a role in genocide, slavery, and the rise and fall of civilizations, all of which have been at least partly due to misperceptions about what it means to have more or less melanin in the skin. Another study showed that systemic melanin-covered nanoparticle (MN) administration reduced hematologic toxicity in mice treated with radiation and that these structures provide efficient protection to bone marrow against radiotoxicity during radioimmunotherapy and in some cases external beam radiation therapy, permitting the administration to tumors of significantly higher doses [117]. Home > Melanin is a substance in the skin that produces skin pigmentation. [34] reported that the extracellular melanin produced by the fungus S. commune was effective against human epidermoid larynx carcinoma cell line (HEP-2) in a concentration-dependent manner, indicating its potential application in cancer chemoprevention and chemotherapy. By Liviu Feller, Razia A.G. Khammissa and Johan Lemme IntechOpen Limited Several studies have shown that the composition of the growth medium, nature and concentration of carbon and nitrogen sources, minerals, vitamins, temperature, pH, the presence of oxygen and aeration, light, stress, and irradiation, among others, affect the growth and pigment production in fungi and that the manipulation of the culture conditions can result in enhanced pigment production [4147]. neuromelanin. A study performed with melanin nanoparticles as biocompatible drug nanocarriers, using metronidazole (antibiotic drug), showed that melanin could be a very interesting nanocarrier drug release device because it strongly responds to pH, being a very interesting feature for the treatment of intestine and colon diseases, which would greatly benefit with pH targeting [142]. Goodman and Bercovich, Melanin Directly Converts Light for VertebrateMetabolic Use, 190-202. In our study with the hypermelanized mutant (MEL1) from A. nidulans, we observed an increase in the production of pigment when the initial pH of the culture was at 6.8 compared to pH 8.0 [50]. The answer may be found in an article published in theJournalof Alternative and Complementary Medicine, in which Geoffrey Goodman and Dani Bercovich hypothesize that melanin may account for the reduction in body hair that occurred 2 million years ago, in an evolutionary trade-off that exchanged the endothermically protective coat of hair for the benefits conferred by melanin-mediated harvesting ofsunlight. Llaila O. Afrika. In a similar study, [56] noted that the production of pigment by Monascus species also was favored when the fungus was grown in the dark. A great deal of the research at present defy a comprehensive standards based approach. Hairlessness would have increased our ability to produce vitamin D, an essential component for neurological development and the neuroplasticity and interconnectivity essential for intelligencenot to mention for the stability of our entire genome. Rate this book. However, melanin has been observed to have other functions such as neuroprotection and energy production. Addeddate 2018-06-15 13:47:24 Identifier MelaninWhatMakesBlackPeopleBlackByLlailaAfrikaPDF Identifier-ark ark:/13960/t6zw89t9z Ocr ABBYY FineReader 11.0 (Extended OCR) In species of Monascus, the pH influences the yield and quality of the produced pigment, with the highest red pigment excretion and production at alkaline pH [51, 52]. Synthetic melanin thin films deposited by spray-coating presented features ascribed to an amorphous semiconducting material [134]. Buy on Amazon. In another provocative study published in the journalToxicology and Applied Pharmacology, researchers extracted melanin from the fungusGliocephalotrichum simplexand gave it to mice just before exposing them to gamma radiation, increasing their 30-day survival by 100 percent. In addition, this pigment has a considerable interest biotechnological because it can be produced on a large scale with low cost, making its use for future practical applications economically advantageous. 2,799 views May 25, 2018 163 Dislike Share REEL NAGAS 28.5K subscribers Order Your Copy of the Great Book of Melanin Research Today!!! WebIn his book The Science & Myth of Melanin Dr. Timothy Moore states that Melanin is more than just a pigment and is found many areas of the body besides the skin. Albertus B. Mostert et al., Role of Semiconductivity and Ion Transport in the Electrical Conduction of Melanin,Proceedings of the National Academy of Sciences109, no. This book, is designed to familiarize the Black Human with Melanin and its importance to life, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. Similar results were also observed for melanin from Ophiocordyceps sinensis, which proved to be an effective DPPH radical scavenger and a strong ferrous iron chelator [105]. 1: the Great Oracle of Tehuti and the Egyptian System of Spiritual Cultivation by Ra Un Nefer Amen Some fungal species produce a dark-brown pigment, known as melanin, by oxidative polymerization of phenolic compounds, such as glutaminyl-3,4-dihydroxybenzene (GDHB) or catechol or 1,8-dihydroxynaphthalene (DHN) or 3,4-dihydroxyphenylalanine (DOPA). A great deal of the research at present defy a comprehensive standards based approach. WebIn his book The Science & Myth of Melanin Dr. Timothy Moore states that Melanin is more than just a pigment and is found many areas of the body besides the skin. $33.33. 103 pages, Paperback Published September 1, 2001 According to the same authors, the melanin is also an effective vehicle for the transport of boron to cancerous sites in the body, mainly when the cancerous cells to be treated are located in the brain, because this pigment binds boron very strongly. As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. To date our community has made over 100 million downloads. By making research easy to access, and puts the academic needs of the researchers before the business interests of publishers. A state of the art facility which uses disciplined scholarship to ascertain objective knowledge regarding melanin and maintain a database of such knowledge would help to expand the awareness of melanin and its actual characteristics. WebGREAT BOOK OF MELANIN RESEARCH PUBLIC OFFICIAL BONDS BOOK (POB) Public Official Bonds - Make Them Pay!!! Studies have shown that one of the major causes of aging is the surplus free radicals produced during the oxidative metabolism in the human body [108]. Capture a web page as it appears now for use as a trusted citation in the future. The production of DOPA-melanin has also been investigated in other fungi such as Neurospora crassa [94], Podospora anserina [95], A. nidulans [91], A. oryzae, and C. neoformans [96]. According to Dr Timothy Moore In humans, melanin is the primary determinant of skin and hair colour 23 (2012): 8943-47,https://doi.org/10.1073/pnas.1119948109. Want to read. C. neoformans, a pathogenic basidiomycetous yeast, is known to synthesize DOPA-melanin when o-diphenolic compounds, such as 3,4-dihydroxyphenylalanine, are present in the culture medium. The same enzyme, tyrosinase, carries out both steps. :). I) by Carol Barnes Melanin: The Organizing Molecule Berkley CA: Institute for the Study of Consciousnesses (Thesis) Message To The Blackman in America by Elijah Muhammad Metu Neter Vol. The development of these higher cognitive processes allowed for the materialization of sophisticated technologies, the agrarian revolution, hierarchical social structure, and advanced human civilizations. Llaila O. Afrika. Scheme adapted from Ref. The nontoxic and nonpathogenic natures, coupled with easy separation from cell biomass, are also preferred qualities. This workis reproduced and distributedwith the permission of GreenMedInfo LLC. Two examples of such therapeutic agents that will cross the blood-brain barrier when linked to melanin are boron and nerve growth factor. Access to Any Private Q&A Livestream With Me! Revitalise Your Life Through Absurdity Therapy, Meditation, Yoga, Grounding & Mindfulness, REGENERATE: Unlocking Your Bodys Radical Resilience Through The New Biology, The New Biophysics of Energy Synthesis: How the Body Harvests Natures Alternative Energy Sources to Power Cellular Pathways, Build Resilience, and Promote Our Evolutionary Edge, https://doi.org/10.1111/j.1349-7006.2004.tb03325.x, https://doi.org/10.2174/1871524915666150203093656, https://doi.org/10.1016/j.mehy.2008.03.038, https://doi.org/10.1016/j.mehy.2015.01.032, https://doi.org/10.1016/j.jenvrad.2007.11.020, https://doi.org/10.1371/journal.pone.0000457, https://doi.org/10.1016/j.bioelechem.2011.04.009, https://doi.org/10.1016/j.taap.2012.08.002, International Journal of Human Nutrition and Functional Medicine, Why Some Scientists Resist the Evidence for Psi, Why Daily Greens are the Real Fountain of Youth, The Power of Peppermint: 15 Health Benefits Revealed. The extracellular fungal melanin, which is found in culture fluids usually in the form of granules, can be formed from some culture components, which are autoxidized or are oxidized by phenoloxidases released from the fungus during autolysis [10, 11, 27]. The biosynthetic pathway of the dihydroxyphenylalanine (DOPA)-melanin in fungi. Introductory Chapter: Melanin, a Versatile Guardia Department of Biochemistry and Technology Chemistry, Institute of Chemistry, UNESP, So Paulo State University, Araraquara, So Paulo, Brazil, Institute of Naturals and Exacts Sciences, UFMT, Mato Grosso Federal University, Rondonopolis, Mato Grosso, Brazil, Department of Pharmaceutical Sciences, UFES, Espirito Santo Federal University, Vitria, Espirito Santo, Brazil. In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. Academia.edu no longer supports Internet Explorer. In experimental models, melanin can successfully shield bone marrow from such side effects. After 13 days, all the mice in the control group had died, and the mice that ate the nonmelaninized porcini mushrooms died almost as fast as the controls. Humans with lighter skin tones may have gained vitamin D accessibility at the expense of the ability to convert sunlight into metabolic energy. One partial explanation for its seeming supernatural capability is that the animals pecten, which is found enlarged in migrating birds who are subject to stressors such as hunger, thirst, hypoxia, and gravity, help the albatross contend with the elements by mediating the melanin-driven conversion of light to metabolic energy. You can download the paper by clicking the button above. This pigment protects the conidia against digestion by proteases and hydrolases secreted by competitive microorganisms or against bactericidal and fungicidal proteins of animal origin, such as defensins, magainins, or protegrins [22]. The Management of Quality in Construction, Political Science. About the author. The metal chelation properties of melanin offer interesting possibilities for melanin-based metal ion sensing. Despite the difference in their origins, melanin pigments have a number of common characteristics that allow them to fulfill their protective function. UNITED KINGDOM, Sandra R. Pombeiro-Sponchiado, Gabriela S. Sousa, Jazmina C. R. isolated from a wall surface, suggesting the application of these nanoparticles as effective paint additives. WebMelanin, the What, the Why and the How: An Introductory Review for Materials Scientists Interested in Flexible and Versatile Polymers A. Bernardus Mostert Citation:Mostert, A.B. A second group of mice was fed white, melanin-poor porcini mushrooms, a third group ate white porcini mushrooms that were supplemented with melanin, and a final control group received no mushrooms or melanin at all. The evolutionary reason, however, is hard to pin down. WebIt is in the melanocytes that melanin is produced. WebTHE GREAT BOOK OF MELANIN RESEARCH!!! A study conducted in our laboratory evaluated the use of corn steep liquor, sugarcane bagasse, and molasses as nutritional source on pigment production by melanin-overproducing mutant (MEL1) from A. nidulans. A state of the art facility which uses disciplined scholarship to ascertain objective knowledge regarding melanin and maintain a database of such knowledge would help to expand the awareness of melanin and its actual characteristics. 2017 The Author(s). Ask About Promo Code. A further dehydration step leads to the intermediate 1,8-dihydroxynaphthalene (DHN), which is polymerized to DHN-melanin, possibly by a laccase enzyme [10, 13, 27]. From trees to flowers to food to energy you will find this one extremely rare. Edited by Vittorio Brena Back To Tokyo / Yesenia. Study conducted by [154] showed that a melanin-rich strain of the fungus Cladosporium cladosporioides biosorbed 2.5- to 4-fold more Ni, Cu, Zn, Cd, and Pb ion than non-melanic Penicillium digitatum. These authors concluded that the cultivation in the total absence of light increased biomass and production of extracellular and intracellular pigments in all fungi. It has been reported that fungal melanin arranged in nanoparticles protects against extremely high levels of ionizing radiation and suggests that the protective efficacy of this pigment is a function of its chemical structure, the presence of stable free radical, and spatial arrangement [18]. Lora Mangum Shields, L. W. Durrell, and Arnold H. Sparrow,Preliminary Observations on Radiosensitivity of Algae and Fungifrom Soils of the Nevada Test Site,Ecology42, no. Publishing on IntechOpen allows authors to earn citations and find new collaborators, meaning more people see your work not only from your own field of study, but from other related fields too. It has taken me 10 years of heavy research and application to be able to bring you this information. The melanin-mediated nanostructures with broad-spectrum antimicrobial activity against food pathogens may be considered suitable for many practical food packaging applications because they can effectively inhibit the growth of pathogens and increase the shelf life of packed food products [124]. Based on these results, we suggest that the melanin produced by A. nidulans does not cause significant damage to the cellular components and might be used in the future for development of new therapeutic drugs [32]. This study suggested that A. auricular melanin inhibits quorum-sensing (QS)-regulated biofilm formation in all strains tested without interfering with their growth [122]. In general, glucose, an excellent carbon source for growth, interferes with the formation of many secondary metabolites, including pigments. In A. nidulans strains, one tyrosinase was identified as the enzyme responsible for the production of melanin pigment, based on its substrate specificity (DOPA substrate) and susceptibility to inhibitors [91, 92]. Due to a planned power outage on Friday, 1/14, between 8am-1pm PST, some services may be impacted. WebFor those important aspects of pigment cell research that do not fall entirely within the scope of the study, such as human cutaneous melanoma or non-cutaneous melanogenesis, and for a more detailed discussion of melanins, melanogenesis, and their applications, the readers are referred to a number of reviews (e.g. 50% Discount on the Remaining Status Law Classes NOT on Patreon! This strategy may represent an added value to the industry and also helps in solving pollution problems, reducing or preventing their disposal in the environment [1, 66, 67]. It has been reported that melanin protects melanocytes and keratinocytes from the induction of DNA strand broken by hydrogen peroxide, indicating that this pigment also has an important antioxidant role in the skin [107]. All the mice were administered high levels of radiation, far surpassing the dose considered dangerous for humans. Potential also exists to use melanin films as an effective radiation sensitizer that could greatly improve the spectral range and efficiency of superconducting transition-edge bolometers [137]. 24. The melanin pigment is not essential for fungal development, but it has been reported to act as fungal armor due to its ability to protect the microorganisms from harmful environmental conditions. [13]. This book is designed to familiarize the reader with Melanin and its chemical key to life and ALL living things, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. WebLiving Color is the first book to investigate the social history of skin color from prehistory to the present, showing how our body's most visible trait influences our social interactions in profound and complex ways. WebGREAT BOOK OF MELANIN RESEARCH PUBLIC OFFICIAL BONDS BOOK (POB) Public Official Bonds - Make Them Pay!!! It has been reported that various types of peptone, used as a nitrogen source, are able to promote an increase in the production of pigments in many species of fungi [55, 59, 62, 63]. IV, Computational Cell Biology: v. 20 (Interdisciplinary Applied Mathematics), Methods and Tools for Collaborative Networked Organizations. I have summarised and bulletpointed his main points. Cracks in 100% nearly all topic of importance to you, like. This strategy may be used to improve nanomaterials with potential applications as efficient catalysts and electrocatalysts. We are also more exposed to ultraviolet light, which degradesfolatein the human body, leaving fetuses more likely to develop neural tube defects. The chemical energy liberated via the dissociation and subsequent charge separation of the water molecule by melanin, in fact, has been estimated to meet over 90 percent of cellular energy needs.17, Research on the melanin-rich intraocular organ pecten in birds explains many phenomena that have eluded scientific explanation, including avian metabolism, bioenergetics, and flight mechanics, and gives us clues about our own bodies ability to use melanin for the purposes of energy. Melanin is a biological molecule associated with pigmentation in humans and animals. The fungi grown under red light have no effect, and green or yellow light resulted in worsening effect in all the fungi, thus postulating the existence of photoreceptors responsive to dark and light in all the fungi. The fungi in both studies were darkly colored and immensely rich in melanin. and Alternaria alternata (Fr.) Gerald H. Pollack, Xavier Figueroa, and Qing Zhao, Molecules, Water, andRadiant Energy: New Clues for the Origin of Life,International Journal ofMolecular Sciences10, no. Watch on QUALIFIED IMMUNITY PACKAGES POLICE STOP/ LAW & GOV FLASHCARDS (PSFC) & (LGFC) In literature, studies have confirmed that fungal melanin acts as metal chelators, enhancing the biomass-metal interaction and consequently its biosorption capacity [14]. There is experimental evidence that fungal melanin may also act as an anti-aging drug, due to its action in reducing the generation of free radicals, clearing away the free radicals produced in excess, and enhancing the activities of antioxidant enzymes. This study demonstrated that toxin-induced Parkinsons disease could be prevented in the melanin-treated animals because the administered melanin causes chelation or scavenging of toxins, such as MPTP, thus preventing a neurodegenerative disease, such as Parkinsons disease. WebMelanin, the What, the Why and the How: An Introductory Review for Materials Scientists Interested in Flexible and Versatile Polymers A. Bernardus Mostert Citation:Mostert, A.B. #THE-LUCIFERIAN-DOCTRINE%^ACHIEVE.!EVERYTHING.THAT.YOU.TRULY. Since melanin has a stable free radical population, it is thought that the radioprotective properties of this pigment result from a combination of physical shielding and quenching of cytotoxic free radicals generated by radiation [18]. Since melanin has a stable free radical population, it is thought that the radioprotective properties of this pigment result from a combination of physical shielding and quenching of cytotoxic free radicals generated by radiation [18]. The albatross, for instance, is capable of traveling 10,000 miles in a single flight, a bioenergetic feat that has long baffled the scientific community. Research on the melanin-rich intraocular organ pecten in birds explains many phenomena that have eluded scientific explanation, including avian metabolism, bioenergetics, and flight mechanics, and gives us clues about our own bodies ability to use melanin for the purposes of energy. 23. Melanin pigment extracted from several fungal species has shown the ability to scavenge free radicals (reactive nitrogen and oxygen species), becoming a potential natural antioxidant. The electrical conductivity properties of this biopolymer are similar to those of amorphous semiconductor solids, and then it can be considered an organic semiconductor, which is largely available and biocompatible and, consequently, cheaper and easier to process with respect to inorganic semiconductors, as silicon germanium. These results can be explained by melanin or other natural pigments present in the cell wall of these fungi that can act as the radiation receptor and/or as an energy transporter for metabolism. The probable mechanism of action was suggested by a study published inBioelectrochemistry,30in which ionizing radiation was found to alter melanins oxidation-reduction potential. @DESIRE | You #Enslave or are-Enslaved. 103 pages, Paperback Published September 1, 2001 pheomelanin. The influence of light on intra- and extracellular pigment production was studied in five pigment-producing fungi: M. purpureus, Isaria farinosa, Emericella nidulans, Fusarium verticillioides, and Penicillium purpurogenum [55]. Made over 100 million downloads separation from cell biomass, are also more exposed to light... Separation from cell biomass, are also preferred qualities you can download the paper by clicking the above. Both steps Biology: v. 20 ( Interdisciplinary Applied Mathematics ), and. Mice were administered high levels of radiation, far surpassing the dose considered dangerous for humans the melanocytes that is. 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Produces skin pigmentation the human body, and appears in homo-sapiens a mere 3 weeks after conception several! Public OFFICIAL BONDS BOOK ( POB ) PUBLIC OFFICIAL BONDS - Make Them Pay!!. Origins, melanin Directly Converts light for VertebrateMetabolic Use, 190-202 origins, melanin pigments have number! A substance in the melanocytes that melanin is a substance in the total absence of light increased and. Coupled with easy separation from cell biomass, are also preferred qualities a... Darkly colored and immensely rich in melanin sunlight into metabolic energy melanin pigments have number. Page as it appears now for Use as a trusted citation in skin. Successfully shield bone marrow from such side effects of radiation, far surpassing dose. Source for growth, interferes with the formation of many secondary metabolites, pigments! [ 134 ] Classes NOT on Patreon nontoxic and nonpathogenic natures, coupled with easy separation from biomass. 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